|
KMID : 0377619760310050541
|
|
Korean Jungang Medical Journal
1976 Volume.31 No. 5 p.541 ~ p.543
|
|
|
A Clinical Study of Solantal(Tiaramide) in Surgical Patients
|
|
Lee Hak-Sup
Lee Sun-Ryang
Lee Chan-Young
|
|
|
Abstract
|
|
|
The main treatment of acute infectious disease in surgical patient is an infusion of antibiotics, although an effect of antibiotics has been deteriolated in chronic status. Therefore many clinician has used combined therapy of antibiotics and anti-inflammatory drugs such as adrenal cortical hormone or non-steroid anti-inflammatory drugs. Adrenal cortical hormone has not been used due to a lots, of compltcations of gastro-intestinal tract and brain.
Acetylsalicylic acid and phenylbutazone has long been used as anti-inflammatory drugs. Phenylbutazone derivatives are activated by -acid base, while Solantal is activated by alkali base, which has been made at Fuzizawa Pharmaceutical Co. as benzothiazoline derivatives, namely Tiaramide.
Clinical studies of Solantal has been made with 45 patients at Surgical. department of National Medical Center, Seoul, Korea. Most of patients were able to take of food early after surgery. Average daily dosage of Solantal were ranged from 300mg to 600mg for shortest 3 days to 20 days. It has been effected against pain-after surgery with 70~80%. In anti-inflammatory effect, it could not been studied by difficult measure of Solantal effect in surgical patient.
Side reaction of Solantal was minimal. with gastrointestinal trouble(0.5%) and itching sensation(0.2%). There has been nothing of complication during long standing use.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|